Simplified PK model — personal reference only. Not medical advice.
Curves are calibrated to measured equimolar data (Dolder et al.) and reported clinical onset: both drugs are converted to delivered d-amphetamine base (Vyvanse mg × 0.296, dex mg × 0.734) with dex absorbing faster (onset ~30min, peak ~3.1h) than the Vyvanse prodrug (onset ~1h, peak ~4.6h), so line heights are directly comparable.
Does not account for individual metabolism, food, pH, or other factors.
Drug is still present below the "wears off" line but clinical effects have largely faded.